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Contributor Information

  • Name Allan Balmain
  • Institute Cancer Research UK, Glasgow: The Beatson Institute

Tool Details

  • Tool name: PDVC57B Cell Line
  • Tool type: Cell Lines
  • Tool sub-type: Continuous
  • Parental cell line: PDV
  • Organism: Mouse
  • Cancer type: Carcinoma Squamous Cell
  • Disease: Cancer
  • Description: The PDVC57B Cell Line is useful for the study of the progression of carcinogenesis and as a model of relapse after surgery. PDVC57B is syngeneic for C57B1/6 mice and carries a p53 mutation in codon 231, (ATG-GTC) and an A-T tranversion at cod 61 of the H-ras gene. These events appear to be remarkably similar to the sequence of changes seen during tumour development in vivo.
  • Research area: Cancer ; Apoptosis and Programmed Cell Death ; Cell Cycle ; Drug Discovery & Development ; Epigenetics & Nuclear Signalling

  • For Research Use Only

Target Details

Application Details

Handling

  • Format: Frozen
  • Growth medium: DMEM + 2mM Glutamine + 10% Foetal Bovine Serum (FBS).
  • Shipping conditions: Dry ice

Documentation

  • Available on request

References

  •   Clin Cancer Res. 2002 Jun
  •   8(6):1984-94.PMID: 12060644
  •   Quintanilla et al. 1991. Carcinogenesis. 12(10):1875-81. PMID: 1934268.
  •   Comparison of ras activation during epidermal carcinogenesis in vitro and in vivo.