CELL LINES
Contributor Information
- Name Allan Balmain
- Institute Cancer Research UK, Glasgow: The Beatson Institute
Tool Details
- Tool name: PDVC57B Cell Line
- Tool type: Cell Lines
- Tool sub-type: Continuous
- Parental cell line: PDV
- Organism: Mouse
- Cancer type: Carcinoma
- Disease: Cancer
- Growth properties: Mouse spindle cell carcinoma, Adherent
- Model: Tumour line
- Description: The PDVC57B Cell Line is useful for the study of the progression of carcinogenesis and as a model of relapse after surgery. PDVC57B is syngeneic for C57B1/6 mice and carries a p53 mutation in codon 231, (ATG-GTC) and an A-T tranversion at cod 61 of the H-ras gene. These events appear to be remarkably similar to the sequence of changes seen during tumour development in vivo.
- Research area: Cancer; Apoptosis and autophagy; Cell biology; Drug development; Genetics
- Production details: The transformed PDVB57B was created by treating the PDV cell line with the carcinogen DMBA.
- Cellosaurus ID: CVCL_4271
- For Research Use Only
Target Details
- Target: PDVC57b
Application Details
Handling
- Format: Frozen
- Growth medium: DMEM + 2mM Glutamine + 10% Foetal Bovine Serum (FBS).
- Shipping conditions: Dry ice
Documentation
Related Tools
References
- • Clin Cancer Res. 2002 Jun
- • 8(6):1984-94.PMID: 12060644
- • Quintanilla et al. 1991. Carcinogenesis. 12(10):1875-81. PMID: 1934268.
- • Comparison of ras activation during epidermal carcinogenesis in vitro and in vivo.
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