PEO4 Cell Line
- Name Simon Langdon
- Institute Cancer Research UK Edinburgh Centre
Tool name: PEO4 Cell Line
Tool type: Cell Lines
Cancer type: Adenocarcinoma
Growth properties: Adherent
Model: Tumour line
Description: The PEO4 cell line is one of nine from the PE ovarian adenocarcinoma panel (derived from 4 patients at varying stages of ovarian cancer, isolated from various malignant sites, and at various treatment stages) which provides a model system for research into the mechanism of oestrogen action on ovarian adenocarcinoma tumour cells, and for the study of efficacy and toxicity of oestrogen protagonists. PEO4 is an adherent cell line derived from a malignant effusion from the peritoneal ascites of a patient with a poorly differentiated serous adenocarcinoma. The patient previously received cisplatin, 5-fluorouracil and chlorambucil treatment. PEO4 was collected after clinical resistance developed to chemotherapy. PEO4 is tumourigenic in immunologically-deprived CBA mice. PEO4 exhibits good growth in semi-solid medium (agar). PEO4 is from the same patient as the PEO1 and PEO6 cell lines
Research area: Cancer; Drug development
Cellosaurus ID: CVCL_2690
- For Research Use Only
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- • Potent organo-osmium compound shifts metabolism in epithelial ovarian cancer cells.
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- • TRAIL-R2-specific antibodies and recombinant TRAIL can synergise to kill cancer cells.
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- • Oestrogen receptor expression and the effects of oestrogen and tamoxifen on the growth of human ovarian carcinoma cell lines.
- • Langdon et al. 1988. Cancer Res. 48(21):6161-5. PMID: 3167862.
- • Langdon et al. 1988. Cancer Res. 48(21):6166-72. PMID: 3167863.
- • Effect of sodium butyrate and other differentiation inducers on poorly differentiated human ovarian adenocarcinoma cell lines.
- • Characterization and properties of nine human ovarian adenocarcinoma cell lines.