- Name Simon Langdon
- Institute Cancer Research UK Edinburgh Centre
- Tool name: TO14 Cell Line
- Tool type: Cell Lines
- Organism: Human
- Tissue: Ovary
- Cancer type: Adenocarcinoma
- Disease: Cancer
- Growth properties: Adherent
- Conditional: Yes
- Description: The TO14 cell line is one of nine from the PE ovarian adenocarcinoma panel (derived from 4 patients at varying stages of ovarian cancer, isolated from various malignant sites, and at various treatment stages) which provides a model system for research into the mechanism of oestrogen action on ovarian adenocarcinoma tumour cells, and for the study of efficacy and toxicity of oestrogen protagonists. TO14 is an adherent cell line derived from a metastasis to the omentum obtained at hysterectomy from a patient with a well differentiated serous adenocarcinoma. TO14 exhibits poor growth in semi-solid medium (agar). TO14 is from the same patient as PEO23 cell line. This is a oestrogen receptor negative cell line. Cell line morphology: epithelial; stellate in shape and producing hemicystic colonies which grow upwards from the substrate and detach as spheres.
- Research area: Cancer; Drug Discovery & Development
- Cellosaurus ID: CVCL_2734
- For Research Use Only
- • Langdon et al. 1990. Br J Cancer. 62(2):213-6. PMID: 2386737.
- • Oestrogen receptor expression and the effects of oestrogen and tamoxifen on the growth of human ovarian carcinoma cell lines.
- • Langdon et al. 1988. Cancer Res. 48(21):6161-5. PMID: 3167862.
- • Langdon et al. 1988. Cancer Res. 48(21):6166-72. PMID: 3167863.
- • Effect of sodium butyrate and other differentiation inducers on poorly differentiated human ovarian adenocarcinoma cell lines.
- • Characterization and properties of nine human ovarian adenocarcinoma cell lines.