PEO1-CDDP Cell Line
- Name Simon Langdon
- Institute Cancer Research UK Edinburgh Centre
Tool name: PEO1-CDDP Cell Line
Tool type: Cell Lines
Tool sub-type: Continuous
Parental cell line: PEO1
Cancer type: Adenocarcinoma
Description: The PEO1-CDDP Cell Line is an in-vitro model to understand the changes in EGF signalling after the onset of cisplatin resistance. Coupled with this change in drug sensitivity, this model also has a modified responsiveness to ligands of the erbB receptor family. This model will be helpful in studying the changes in cellular signalling after drug treatment, which are currently attracting a great deal of interest and this model will be of particular relevance when cytotoxic therapy is combined with signalling inhibitors.
Research area: Cancer ; Cell Signaling & Signal Transduction ; Drug Discovery & Development
- For Research Use Only
- • Macleod et al. 2005. Cancer Res. 65(15):6789-800. PMID: 16061661.
- • Altered ErbB receptor signaling and gene expression in cisplatin-resistant ovarian cancer.