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Contributor Information

  • Name Simon Langdon
  • Institute Cancer Research UK Edinburgh Centre

Tool Details

  • Tool name: PEO1-CDDP Cell Line
  • Tool type: Cell Lines
  • Tool sub-type: Continuous
  • Parental cell line: PEO1
  • Organism: Human
  • Tissue: Ovary
  • Cancer type: Adenocarcinoma
  • Disease: Cancer
  • Description: The PEO1-CDDP Cell Line is an in-vitro model to understand the changes in EGF signalling after the onset of cisplatin resistance. Coupled with this change in drug sensitivity, this model also has a modified responsiveness to ligands of the erbB receptor family. This model will be helpful in studying the changes in cellular signalling after drug treatment, which are currently attracting a great deal of interest and this model will be of particular relevance when cytotoxic therapy is combined with signalling inhibitors.
  • Research area: Cancer ; Cell Signaling & Signal Transduction ; Drug Discovery & Development

  • For Research Use Only

Target Details

Application Details

Handling

  • Format: Frozen
  • Growth medium: RPMI 1640 containing 10% heat-inactivated FCS, penicillin (100 units/mL), and streptomycin (100 ug/mL). Cells were maintained routinely at 37°C in a humidified atmosphere of 5% CO2 in air.
  • Shipping conditions: Dry ice

Documentation

  • Available on request

References

  •   Macleod et al. 2005. Cancer Res. 65(15):6789-800. PMID: 16061661.
  •   Altered ErbB receptor signaling and gene expression in cisplatin-resistant ovarian cancer.