2fTGH-U4C Cell Line
- Name Ian Kerr
- Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Tool name: 2fTGH-U4C Cell Line
Tool type: Cell Lines
Tool sub-type: Continuous
Parental cell line: HT 1080
Cancer type: Fibrosarcoma
Description: The 2fTGH-U4C Cell Line is part of a panel of IFNy pathway mutant fibrosarcoma cell lines isolated by chemical mutagenesis of IFNy insensitive reporter cells derived from HT1080 cells. Knockout genes have been identified and span multiple members of the IFMy pathway. These cell lines are be useful for the in vitro study and comparison of disrupted interferon signalling at multiple points across the IFN pathway.
The following cell lines are part of the group of IFN signalling mutants: U4C, U2A, U3A, 2FTGH, U6A, U5A. Each containing a different mutation in the IFN signalling pathway.
Research area: Cancer ; Cell Signaling & Signal Transduction ; Immunology
- For Research Use Only
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- • Use of a selectable marker regulated by alpha interferon to obtain mutations in the signaling pathway.