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Contributor Information

  • Name Tomas Lindahl
  • Institute Cancer Research UK, London Research Institute: Clare Hall Laboratories

Tool Details

  • Tool name: MEF OGG1 KO Cell Line
  • Tool type: Cell Lines
  • Organism: Mouse
  • Tissue: Embryo
  • Description: The MEF OGG1 KO cell line can be used to assess the role of the mammalian enzyme OGG1 in repair of DNA damage and prevention of carcinogenesis. the cell line can be used to assess the incidence and consequences of 8-oxoG formation in the mammalian genome.
  • Research area: Cancer ; DNA Damage and Repair ; Drug Discovery & Development

  • For Research Use Only

Target Details

Application Details

Handling

  • Format: Frozen
  • Growth medium: DMEM/Ham's F-12 (3:1) with 10% FBS
  • Shipping conditions: Dry ice

Documentation

  • Available on request

References

  •   Klungland et al. 1999. Proc Natl Acad Sci U S A. 96(23):13300-5. PMID: 10557315.
  •   Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage.