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Contributor Information

  • Name Anne Lykkesfeldt
  • Institute Danish Cancer Society

Tool Details

  • Tool name: T47D/S5 Cell Line
  • Tool type: Cell Lines
  • Tool sub-type: Continuous
  • Parental cell line: T47D
  • Organism: Human
  • Tissue: Breast
  • Cancer type: Breast cancer
  • Disease: Cancer
  • Application: T47DS5 cells express ER alpha and progesterone receptor.
  • Description: The T47D/S5 Cell line is the control for the fulvestrant resistant T47D/182R-1 and T47D/182R-2 cell lines. Antiestrogen resistance is a major problem in breast cancer treatment. Therefore, the search for new therapeutic targets and biomarkers for antiestrogen resistance is crucial.
  • Research area: Cancer ; Drug Discovery & Development

  • For Research Use Only

Target Details

Application Details

  • Application: T47DS5 cells express ER alpha and progesterone receptor.

Handling

  • Format: Frozen
  • Passage number: Passage 155 (AL3043, AL3044)
  • Growth medium: Phenol red free RPMI 1640 + 5% FCS + glutamax + 8Âľg Insulin/ml
  • Shipping conditions: Dry ice

Documentation

  • Available on request

References

  •   Larsen et al. 2015. PLoS One. 10(2):e0118346. PMID: 25706943.
  •   Larsen et al. 2015. BMC Cancer. 15:239. PMID: 25885472.
  •   Aurora kinase B is important for antiestrogen resistant cell growth and a potential biomarker for tamoxifen resistant breast cancer.
  •   SRC drives growth of antiestrogen resistant breast cancer cell lines and is a marker for reduced benefit of tamoxifen treatment.
  •   Thrane et al. 2014. Oncogene. :. PMID: 25362855.
  •   A kinase inhibitor screen identifies Mcl-1 and Aurora kinase A as novel treatment targets in antiestrogen-resistant breast cancer cells.
  •   Kirkegaard et al. 2014. Cancer Lett. 344(1):90-100. PMID: 24513268.
  •   T47D breast cancer cells switch from ER/HER to HER/c-Src signaling upon acquiring resistance to the antiestrogen fulvestrant.