S_M6R1 Cell Line
- Name John Lunec
- Institute Newcastle University
Tool name: S_M6R1 Cell Line
Tool type: Cell Lines
Tool sub-type: Continuous
Parental cell line: SJSA-1
Cancer type: Osteosarcoma; Multipotential sarcoma
Description: To determine how resistance to MDM2/p53 binding antagonists might develop, SJSA-1 cells were exposed to growth inhibitory concentrations of a MDM2 inhibitor, MI-63, and a clonal resistant cell line was generated. The p53 mediated responses of the parental and resistant cell line were compared. In contrast to the parental cell lines, p53 activation by Nutlin-3, MI-63 or ionizing radiation was not observed in the SJSA-1 derived cell line, S-M6R1.
Research area: Cancer ; Apoptosis and Programmed Cell Death ; Cell Cycle ; Drug Discovery & Development ; Epigenetics & Nuclear Signalling
- For Research Use Only
- • TP53 mutant MDM2-amplified cell lines selected for resistance to MDM2-p53 binding antagonists retain sensitivity to ionizing radiation.
- • Drummond et al. 2016. Oncotarget. :. PMID: 27323823.