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Contributor Information

  • Name Eric Kenneth Parkinson
  • Institute Cancer Research UK, Glasgow: The Beatson Institute

Tool Details

  • Tool name: BICR 10 Cell Line
  • Tool type: Cell Lines
  • Organism: Human
  • Tissue: Buccal mucosa
  • Cancer type: Head and neck cancer
  • Disease: Cancer
  • Growth properties: Adherent
  • Model: Tumour line
  • Description: Adherent keratinocyte cell line derived from a recurrent squamous cell carcinoma of the buccal mucosa of a Caucasian female. Keratin and involucrin markers present. Known mutations: p53, p16 and p14ARF. Cells are tumourigenic in athymic mice.
  • Research area: Cancer; Apoptosis and autophagy; Drug development; Genetics
  • Cellosaurus ID: CVCL_2307

  • For Research Use Only

Target Details

Application Details

  • Application notes: STR-PCR Data: Amelogenin: X CSF1PO: 12,14 D13S317: 8,14 D16S539: 9,13 D5S818: 11,13 D7S820: 11,12 THO1: 9.3 TPOX: 8 vWA: 17

Handling

  • Format: Frozen
  • Growth medium: DMEM + 2mM Glutamine + 10% Foetal Bovine Serum (FBS) + 0.4 micrograms/ml Hydrocortisone.
  • Shipping conditions: Dry ice

Documentation

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References

  • •  Edington et al. 1995. Mol Carcinog. 13(4):254-65. PMID: 7646764.
  • •  Cellular immortality: a late event in the progression of human squamous cell carcinoma of the head and neck associated with p53 alteration and a high frequency of allele loss.