CELL LINES
Contributor Information
- Name Eric Kenneth Parkinson
- Institute Cancer Research UK, Glasgow: The Beatson Institute
Tool Details
- Tool name: BICR 18 Cell Line
- Tool type: Cell Lines
- Organism: Human
- Tissue: Larynx
- Cancer type: Larynx squamous cell carcinoma (lymph node metastasis)
- Disease: Cancer
- Growth properties: Adherent
- Model: Tumour line
- Conditional: Yes
- Description: Adherent keratinocyte cell line derived from a lymph node metastasis squamous cell carcinoma (SSC) of the larynx. Keratin and involucrin markers present. Known mutations: p53, p16 and p14ARF. Cells are tumourigenic in athymic mice. By short tandem repeat (STR)-PCR analysis the Y chromosome could not be detected in this cell line. It is a known phenomenon that SSC cell lines can lose their Y chromosome.
- Research area: Cancer; Apoptosis and Programmed Cell Death; Drug Discovery & Development; Epigenetics & Nuclear Signalling
- Cellosaurus ID: CVCL_2309
- Additional notes: STR-PCR Data: Amelogenin: X CSF1PO: 11,12 D13S317: 8,13 D16S539: 12,14 D5S818: 12 D7S820: 9 THO1: 7 TPOX: 9,12 vWA: 17,20
- For Research Use Only
Target Details
Application Details
- Application notes: STR-PCR Data: Amelogenin: X CSF1PO: 11,12 D13S317: 8,13 D16S539: 12,14 D5S818: 12 D7S820: 9 THO1: 7 TPOX: 9,12 vWA: 17,20
Handling
- Format: Frozen
- Growth medium: DMEM + 2mM Glutamine + 10% Foetal Bovine Serum (FBS) + 0.4 micrograms/ml Hydrocortisone.
- Shipping conditions: Dry ice
Documentation
- Available on request
Related Tools
References
- • Edington et al. 1995. Mol Carcinog. 13(4):254-65. PMID: 7646764.
- • Cellular immortality: a late event in the progression of human squamous cell carcinoma of the head and neck associated with p53 alteration and a high frequency of allele loss.
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