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Contributor Information

  • Name Eric Kenneth Parkinson
  • Institute Cancer Research UK, Glasgow: The Beatson Institute

Tool Details

  • Tool name: BICR 18 Cell Line
  • Tool type: Cell Lines
  • Parental cell line:
  • Organism: Human
  • Tissue: Larynx
  • Cancer type: Larynx squamous cell carcinoma (lymph node metastasis)
  • Disease: Cancer
  • Conditional: Yes
  • Description: Adherent keratinocyte cell line derived from a lymph node metastasis squamous cell carcinoma (SSC) of the larynx. Keratin and involucrin markers present. Known mutations: p53, p16 and p14ARF. Cells are tumourigenic in athymic mice. By short tandem repeat (STR)-PCR analysis the Y chromosome could not be detected in this cell line. It is a known phenomenon that SSC cell lines can lose their Y chromosome.
  • Research area: Cancer ; Apoptosis and Programmed Cell Death ; Drug Discovery & Development ; Epigenetics & Nuclear Signalling

  • For Research Use Only

Target Details

Application Details

Handling

  • Format: Frozen
  • Growth medium: DMEM + 2mM Glutamine + 10% Foetal Bovine Serum (FBS) + 0.4 micrograms/ml Hydrocortisone.
  • Shipping conditions: Dry ice

Documentation

  • Available on request

References

  •   Edington et al. 1995. Mol Carcinog. 13(4):254-65. PMID: 7646764.
  •   Cellular immortality: a late event in the progression of human squamous cell carcinoma of the head and neck associated with p53 alteration and a high frequency of allele loss.