BICR 18 Cell Line
- Name Eric Kenneth Parkinson
- Institute Cancer Research UK, Glasgow: The Beatson Institute
Tool name: BICR 18 Cell Line
Tool type: Cell Lines
Cancer type: Larynx squamous cell carcinoma (lymph node metastasis)
Growth properties: Adherent
Model: Tumour line
Description: Adherent keratinocyte cell line derived from a lymph node metastasis squamous cell carcinoma (SSC) of the larynx. Keratin and involucrin markers present. Known mutations: p53, p16 and p14ARF. Cells are tumourigenic in athymic mice. By short tandem repeat (STR)-PCR analysis the Y chromosome could not be detected in this cell line. It is a known phenomenon that SSC cell lines can lose their Y chromosome.
Research area: Cancer; Apoptosis and Programmed Cell Death; Drug Discovery & Development; Epigenetics & Nuclear Signalling
Cellosaurus ID: CVCL_2309
Additional notes: STR-PCR Data:
- For Research Use Only
- • Edington et al. 1995. Mol Carcinog. 13(4):254-65. PMID: 7646764.
- • Cellular immortality: a late event in the progression of human squamous cell carcinoma of the head and neck associated with p53 alteration and a high frequency of allele loss.