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Contributor Information

  • Name Eric Kenneth Parkinson
  • Institute Cancer Research UK, Glasgow: The Beatson Institute

Tool Details

  • Tool name: BICR 3 Cell Line
  • Tool type: Cell Lines
  • Organism: Human
  • Tissue: Alveolus
  • Cancer type: Alveolus squamous cell carcinoma
  • Disease: Cancer
  • Growth properties: Adherent
  • Model: Tumour line
  • Conditional: Yes
  • Description: Adherent keratinocyte cell line derived from a squamous cell carcinoma of the alveolus of a Caucasian female. Keratin and involucrin markers present. Known mutations: p53 and p16. Cells are tumourigenic in athymic mice. Epidermal Growth Factor Receptor (EGFR) present.
  • Research area: Cancer; Apoptosis and Programmed Cell Death; Drug Discovery & Development; Epigenetics & Nuclear Signalling
  • Cellosaurus ID: CVCL_2311
  • Additional notes: STR-PCR Data: Amelogenin: X, X CSF1PO: 11,12 D13S317: 8,13 D16S539: 11 D5S818: 11,12 D7S820: 10,13 THO1: 6,7 TPOX: 8 vWA: 14,19

  • For Research Use Only

Target Details

Application Details

  • Application notes: STR-PCR Data: Amelogenin: X, X CSF1PO: 11,12 D13S317: 8,13 D16S539: 11 D5S818: 11,12 D7S820: 10,13 THO1: 6,7 TPOX: 8 vWA: 14,19

Handling

  • Format: Frozen
  • Growth medium: DMEM + 2mM Glutamine + 10% Foetal Bovine Serum (FBS) + 0.4 micrograms/ml Hydrocortisone.
  • Shipping conditions: Dry ice

Documentation

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  • Available on request

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References

  • •  Edington et al. 1995. Mol Carcinog. 13(4):254-65. PMID: 7646764.
  • •  Cellular immortality: a late event in the progression of human squamous cell carcinoma of the head and neck associated with p53 alteration and a high frequency of allele loss.