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Contributor Information

  • Name Eric Kenneth Parkinson
  • Institute Cancer Research UK Glasgow: The Beatson Institute

Tool Details

  • Tool name: BICR 6 Cell Line
  • Tool type: Cell Lines
  • Organism: Human
  • Tissue: Hypopharynx
  • Cancer type: Hypopharynx squamous cell carcinoma
  • Disease: Cancer
  • Growth properties: Adherent
  • Model: Tumour line
  • Conditional: Yes
  • Description: Adherent keratinocyte cell line derived from a squamous cell carcinoma of the hypopharynx of a Caucasian male. Keratin and involucrin markers present. Known mutations: p53, p16 and p14ARF. Cells are tumourigenic in athymic mice. Epidermal Growth Factor Receptor (EGFR) present.
  • Research area: Cancer; Apoptosis and Programmed Cell Death; Drug Discovery & Development; Epigenetics & Nuclear Signalling
  • Cellosaurus ID: CVCL_2314
  • Additional notes: STR-PCR Data: Amelogenin: X, Y CSF1PO: 10 D13S317: 14 D16S539: 11 D5S818: 12 D7S820: 10 THO1: 6 TPOX: 9,11 vWA: 16,17

  • For Research Use Only

Target Details

Application Details

  • Application notes: STR-PCR Data: Amelogenin: X, Y CSF1PO: 10 D13S317: 14 D16S539: 11 D5S818: 12 D7S820: 10 THO1: 6 TPOX: 9,11 vWA: 16,17

Handling

  • Format: Frozen
  • Growth medium: DMEM + 2mM Glutamine + 10% Foetal Bovine Serum (FBS) + 0.4 micrograms/ml Hydrocortisone.
  • Shipping conditions: Dry ice

Documentation

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  • Available on request

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References

  • •  Edington et al. 1995. Mol Carcinog. 13(4):254-65. PMID: 7646764.
  • •  Cellular immortality: a late event in the progression of human squamous cell carcinoma of the head and neck associated with p53 alteration and a high frequency of allele loss.