CELL LINES

Contributor Information
- Name Eric Kenneth Parkinson
- Institute Cancer Research UK Glasgow: The Beatson Institute
Tool Details
- Tool name: BICR 6 Cell Line
- Tool type: Cell Lines
- Organism: Human
- Tissue: Hypopharynx
- Cancer type: Hypopharynx squamous cell carcinoma
- Disease: Cancer
- Growth properties: Adherent
- Model: Tumour line
- Conditional: Yes
- Description: Adherent keratinocyte cell line derived from a squamous cell carcinoma of the hypopharynx of a Caucasian male. Keratin and involucrin markers present. Known mutations: p53, p16 and p14ARF. Cells are tumourigenic in athymic mice. Epidermal Growth Factor Receptor (EGFR) present.
- Research area: Cancer; Apoptosis and Programmed Cell Death; Drug Discovery & Development; Epigenetics & Nuclear Signalling
- Cellosaurus ID: CVCL_2314
- Additional notes: STR-PCR Data: Amelogenin: X, Y CSF1PO: 10 D13S317: 14 D16S539: 11 D5S818: 12 D7S820: 10 THO1: 6 TPOX: 9,11 vWA: 16,17
- For Research Use Only
Target Details
Application Details
- Application notes: STR-PCR Data: Amelogenin: X, Y CSF1PO: 10 D13S317: 14 D16S539: 11 D5S818: 12 D7S820: 10 THO1: 6 TPOX: 9,11 vWA: 16,17
Handling
- Format: Frozen
- Growth medium: DMEM + 2mM Glutamine + 10% Foetal Bovine Serum (FBS) + 0.4 micrograms/ml Hydrocortisone.
- Shipping conditions: Dry ice
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References
- • Edington et al. 1995. Mol Carcinog. 13(4):254-65. PMID: 7646764.
- • Cellular immortality: a late event in the progression of human squamous cell carcinoma of the head and neck associated with p53 alteration and a high frequency of allele loss.