HCT 116 EphA2 KO Tet-inducible Cell Line
- Name Sandra Van Schaeybroeck
- Institute Queen's University Belfast
Tool name: HCT 116 EphA2 KO Tet-inducible Cell Line
Tool type: Cell Lines
Tool sub-type: Continuous
Parental cell line: HCT 116
Cancer type: Colorectal cancer
Description: EphA2 is an important regulator of tumour initiation, neo-vascularization and metastasis in a wide range of cancers. The HCT 116 EphA2 KO Tet-inducible cell line was developed to address the involvement of EphA2 where it was shown that silencing of the protein suppressed migration and invasion.
Research area: Cancer ; Cell Structure and Motility ; Drug Discovery & Development
- For Research Use Only
- • Dunne et al. 2016. Clin Cancer Res. 22(1):230-42. PMID: 26283684.
- • EphA2 Expression Is a Key Driver of Migration and Invasion and a Poor Prognostic Marker in Colorectal Cancer.