fR2 Cell Line
- Name Joyce Taylor-Papadimitriou ; Sidney Chang
- Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Tool name: fR2 Cell Line
Tool type: Cell Lines
Parental cell line:
Cancer type: Breast cancer
Description: fR2 cells have been shown to express Muc-1, also known as HMFG-1 antigen, which is a mucin-like component of human milk fat globule membranes. They are positive for keratin 8 and 18, but negative for keratins 4, 6, 7, 10, 13, 14, 16, 17 and 19. Although fR2 is morphologically different from fR5, they have probably been derived from a common precursor cell since the karyotypes are similar. Karyotype analysis revealed hypotetraploidy and several rearrangements involving chromosome 1 and 11 which are frequently found in breast carcinomas and lines derived from metastatic pleural effusions. fR2 cells display anchorage independent growth in soft agar and are positive for SV40 T-antigen. Early passages were non-tumorigenic in nude mice.
Research area: Cancer ; Drug Discovery & Development
- For Research Use Only
- • Chang et al. 1982. Cancer Res. 42(5):2040-53. PMID: 6279290.
- • Establishment and characterization of SV40-transformed human breast epithelial cell lines.