K562 AZQR Cell Line
- Name Timothy Ward
- Institute Cancer Research UK Manchester Institute
Tool name: K562 AZQR Cell Line
Tool type: Cell Lines
Tool sub-type: Continuous
Parental cell line: K562
Tissue: Lymphatic Tissue
Cancer type: Human caucasian chronic myelogenous leukemia (drug resistant)
Description: The cells have been shown to contain decreased levels of glutathione and superoxoid dismutase. They are cross-resistant to adriamycin, mitzolamide, MMNG and mitmycin. Cells should be challenged with AZQ at every 4th passage at a minimum density of 100,000 cells/ml. It is recommended to cultivate the cells without drug on resuscitation.
Research area: Cancer ; Drug Discovery & Development
- For Research Use Only
- • Ward et al. 1995. Biochem Pharmacol. 50(4):459-64. PMID: 7646550.
- • Cross-resistance studies on two K562 sublines resistant to diaziridinylbenzoquinones.