- Name Eyal Gottlieb
- Institute Cancer Research UK, Glasgow: The Beatson Institute
- Tool name: Sdhb -/- CL 5 Cell Line
- Alternate names: Succinate dehydrogenase, SDH, Succinate-coenzyme Q reductase, SQR
- Tool type: Cell Lines
- Organism: Mouse
- Tissue: Kidney
- Disease: Cancer
- Model: Knock-Out
- Description: Succinate dehydrogenase (SDH) is an enzyme complex found in the inner mitochondrial membrane of mammalian mitochondria and many bacterial cells. SDH is the only enzyme that participates in both the electron transport chain and citric acid cycle. The enzymatic function of SDH oxidises succinate to fumarate in the tricarboxylic acid cycle and losing this function is associated with cancer formation.
- Research area: Cancer; Drug Discovery & Development; Metabolism
- Cellosaurus ID: CVCL_HG12
- For Research Use Only
- • Cardaci et al. 2015. Nat Cell Biol. 17(10):1317-26. PMID: 26302408.
- • Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis.