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Contributor Information

  • Name Peter Lane
  • Institute University of Birmingham

Tool Details

  • Tool name: J558L Cell Line secreting OX40L
  • Alternate names: OX4L ligand, CD134, dendritic cells, DCs, Th2, CD525, systemic lupus erythematosus, TXGP1, OX-4L, gp34, TNFSF4, CD4 T cells, cytokine, Tumor necrosis factor receptor superfamily member 4, TNFRSF4
  • Tool type: Cell Lines
  • Tool sub-type: Continuous
  • Parental cell line: J558L - mammalian plasmacytoma cell line
  • Organism: Mouse
  • Description: OX40 receptor also known as CD134, a member of the tumor necrosis factor receptor superfamily of receptors, is not constitutively expressed on resting naive T cells. OX40 is activated 24 to 72 hours after binding to its ligand; OX40L, and is a secondary co-stimulatory immune checkpoint molecule. Expression of OX40 is dependent on full activation of the CD28 absent-T cell.
  • Research area: Immunology

  • For Research Use Only

Target Details

Application Details

Handling

  • Format: Frozen
  • Growth medium:
  • Storage conditions: Liquid Nitrogen
  • Shipping conditions: Dry ice
  • Mycoplasma free: Yes
  • Biosafety level: 1

Documentation

  • Available on request

References

  •   Flynn et al. 1998. J Exp Med. 188(2):297-304. PMID: 9670042.
  •   CD4 T cell cytokine differentiation: the B cell activation molecule, OX40 ligand, instructs CD4 T cells to express interleukin 4 and upregulates expression of the chemokine receptor, Blr-1.