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Contributor Information

  • Name Irene Leigh
  • Institute Queen Mary University of London

Tool Details

  • Tool name: IC1 SCC Cell Line
  • Alternate names: SCC, Squamous cell carcinoma, IC1
  • Tool type: Cell Lines
  • Parental cell line:
  • Organism: Human
  • Tissue: Skin
  • Cancer type: Skin Cancer, Squamous Cell Carcinoma
  • Disease: Cancer
  • Description: IC1 squamous cell carcinoma cell line derived from a primary tumour. Background and Research Application The SCC series represent primary, recurrent and metastatic carcinoma. Availability of such a series from the same individual will facilitate genetic analysis of the malignant process. This cell line has been used in a variety of research, including research in the role of Notch signalling mutations in SCC.
  • Research area: Cancer ; Genetic Studies Tools

  • For Research Use Only

Target Details

Application Details

Handling

  • Format: Frozen
  • Growth medium: Keratinocyte cell culture media supplemented with 10ng/ml EGF
  • Storage conditions: Liquid Nitrogen
  • Shipping conditions: Dry ice
  • Mycoplasma free: Yes
  • Biosafety level: 1

Documentation

  • Available on request

References

  •   Inman et al. 2018. Nat Commun. 9(1):3667. PMID: 30202019.
  •   The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature.
  •   McHugh et al. 2018. Oncotarget. 9(29):20265-20281. PMID: 29755650.
  •   South et al. 2014. J Invest Dermatol. 134(10):2630-2638. PMID: 24662767.
  •   Watt et al. 2011. Oncogene. 30(46):4666-77. PMID: 21602893.
  •   Wang et al. 2011. Proc Natl Acad Sci U S A. 108(43):17761-6. PMID: 22006338.