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Contributor Information

  • Name Robert Lahue
  • Institute National University of Ireland Galway ; Brown University

Tool Details

  • Tool name: SVG-A Msh3 1.7X Cell Line
  • Tool type: Cell Lines
  • Tool sub-type: Continuous
  • Parental cell line: Msh3-/- SVG-A Cell Line
  • Organism: Human
  • Tissue: Brain
  • Description: This cell line was derived from the SVG-A Msh3-/- (knock-out generated by CRISPR)) cell line whereby the DNA mismatch repair protein Msh3 expression has been reinstated.
  • Research area: DNA Damage and Repair ; Neurobiology
  • Additional notes: Cancer Research Technology Limited (trading research tools as CancerTools.org) has been granted a non-exclusive license to the CRISPR-Cas9 technology by ERS Genomics Ltd under the patent rights listed here: https://www.cancertools.org/tool-faqs#hs_cos_wrapper_widget_1649861453796 This license from ERS Genomics Ltd allows CancerTools.org to develop and commercialise CRISPR-Cas9 modified cell lines for research use only. CancerTools.org can provide these modified CRISPR-Cas9 cell lines to companies under a label-use only license

  • For Research Use Only

Target Details

Application Details

Handling

  • Format: Frozen
  • Growth medium: DMEM supplemented with 10% FBS
  • Storage conditions: Liquid Nitrogen
  • Shipping conditions: Dry ice
  • Mycoplasma free: Yes
  • Biosafety level: 1

Documentation

  • Available on request

References

  •   Keogh et al. 2017. MutS? abundance and Msh3 ATP hydrolysis activity are important drivers of CTGCAG repeat expansions. Nucleic Acids Res. 2017 Sep 29
  •   45(17):10068-10078.