Family 1 mother - LAD-III Lymphoblastoid Cell Line
- Name Nancy Hogg
- Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Tool name: Family 1 mother - LAD-III Lymphoblastoid Cell Line
Alternate names: Fermitin family homolog 3, MIG2-like protein, Unc-112-related protein 2
Tool type: Cell Lines
Parental cell line:
Cancer type: Leukocyte Adhesion Deficiency-III (LAD-III)
Description: An EBV-transformed B lymphoblastoid cell line (LCL) derived from the mother of a Maltese subject that has Leukocyte Adhesion Deficiency-III (LAD-III) with a mutation in the kindlin-3 gene. LCLs are also available from the subject, father and subject's sister. This cell line was derived from 'Family 1 mother' as described in Svensson et al. 2009. N.Nat Med. 2009 Mar;15(3):306-12. PMID: 1923446
Research area: Adhesion ; Immunology
- For Research Use Only
- • Svensson et al. 2009. Nat Med. 15(3):306-12. PMID: 19234463.
- • Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation.