Immortalised Human Melanocyte [PIG1] Cell Line
Tool name: Immortalised Human Melanocyte [PIG1] Cell Line
Tool type: Cell Lines
Tool sub-type: Continuous
Parental cell line: Human foreskin
Description: Melanocytes are the cell of origin for a number of conditions including melanoma an aggressive type of skin cancer and vitiligo a long-term condition characterised by patches of the skin losing their pigment. Melanoma is the most dangerous type of skin cancer. Globally, in 2012, it newly occurred in 232,000 people. In 2015 there were 3.1 million with active disease which resulted in 59,800 deaths. Australia and New Zealand have the highest rates of melanoma in the world. While Vitiligo affects 1% of the worlds population with no known cause. Immortalised melanocytes can be used as a tool for research into different melanocytic lineages
Research area: Cancer ; Cell Type or Organelle Marker
- For Research Use Only
- • Ivanova et al. 2008. In Vitro Cell Dev Biol Anim. 44(8-9):385-95. PMID: 18594937.
- • Immortalization of human melanocytes does not alter the de novo properties of nitric oxide to induce cell detachment from extracellular matrix components via cGMP.
- • Le Poole et al. 1997. In Vitro Cell Dev Biol Anim. 33(1):42-9. PMID: 9028834.
- • Generation of a human melanocyte cell line by introduction of HPV16 E6 and E7 genes.