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Contributor Information

  • Institute Northern Institute For Cancer Research, Newcastle University

Tool Details

  • Tool name: LNCaP androgen-independent cell line
  • Tool type: Cell Lines
  • Tool sub-type: Continuous
  • Parental cell line: LNCaP
  • Organism: Human
  • Cancer type: Human prostate adenocarcinoma
  • Disease: Cancer
  • Description: LNCaP cells are androgen-sensitive human prostate adenocarcinoma cells derived from the left supraclavicular lymph node metastasis from a 50-year-old Caucasian male in 1977. The androgen receptor (AR) in LNCaP cells harbours a T877A mutations which enables the anti-androgen flutamide to act as an agonist. This cell line is the most commonly used for prostate cancer research. The cell line is a clonal population of LNCaP cells grown in steroid-depleted conditions for ~4 months. Cells adapted to growth conditions and are now routinely grown in media lacking testosterone
  • Research area: Cancer

  • For Research Use Only

Target Details

Application Details

Handling

  • Format: Frozen
  • Growth medium: RPMI-1640 + 10% FBS
  • Shipping conditions: Dry ice

Documentation

  • Available on request