CELL LINES
Contributor Information
- Institute Northern Institute For Cancer Research, Newcastle University
Tool Details
- Tool name: LNCaP androgen-independent cell line
- Tool type: Cell Lines
- Tool sub-type: Continuous
- Parental cell line: LNCaP
- Organism: Human
- Cancer type: Genitourinary cancer
- Disease: Cancer
- Model: Tumour line
- Conditional: No
- Description: LNCaP cells are androgen-sensitive human prostate adenocarcinoma cells derived from the left supraclavicular lymph node metastasis from a 50-year-old Caucasian male in 1977. The androgen receptor (AR) in LNCaP cells harbours a T877A mutations which enables the anti-androgen flutamide to act as an agonist. This cell line is the most commonly used for prostate cancer research. The cell line is a clonal population of LNCaP cells grown in steroid-depleted conditions for ~4 months. Cells adapted to growth conditions and are now routinely grown in media lacking testosterone
- Research area: Cancer
- Production details: LNCaP cells grown in steroid-depleted conditions for ~4 months
- For Research Use Only
Target Details
Application Details
Handling
- Format: Frozen
- Growth medium: RPMI-1640 + 10% FBS
- Shipping conditions: Dry ice
Documentation
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