ZR-75-1 RAF1 [ZR-RAF1(T2)] cell line
- Name Lambert Dorssers
- Institute Erasmus University Medical Center (Erasmus MC)
Tool name: ZR-75-1 RAF1 [ZR-RAF1(T2)] cell line
Alternate names: Raf-1 Proto-Oncogene, Serine/Threonine Kinase; CRaf
Tool type: Cell Lines
Tool sub-type: Continuous
Parental cell line: ZR-75-1
Cancer type: Mammary ductal carcinoma, estrogen independent
Description: Breast cancer is widely and effectively treated with endocrine treatment. However, in many cases the tumours will eventually progress into an estrogen-independent and therapy-resistant phenotype.
Seven genes including AKT1, AKT2, BCAR1, BCAR2, BCAR3, EGFR2 and GRB7 have been shown to directly underlie estrogen independence in human breast cancer cells. This cell line is part of a panel of 16 cell lines (Cat No 154621-154635, 154642) which have been transfected with these genes, plus the parental (Cat No 154547).
This cell line is a powerful tool for studying the molecular and cellular mechanisms of breast tumour progression, therapy resistance and to test the effectiveness of novel drugs to combat different modes of anti-estrogen insensitivity
Research area: Cancer ; Drug Discovery & Development
- For Research Use Only
- • van Agthoven et al. 2010. Endocr Relat Cancer. 17(1):215-30. PMID: 19966015.