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Contributor Information

  • Name Debra Tonetti
  • Institute University of Illinois Chicago

Tool Details

  • Tool name: PKCa cell line
  • Alternate names: MCF7
  • Tool type: Cell Lines
  • Tool sub-type: Continuous
  • Parental cell line: MCF-7
  • Organism: Human
  • Tissue: Breast
  • Cancer type: Breast Cancer; Tamoxifen Resistance
  • Disease: Cancer
  • Description: Approximately 70% of breast cancer patients have estrogen receptor positive (ER+) tumors. The selective estrogen receptor modulator (SERM), tamoxifen, and aromatase inhibitors (AIs) represent first-line treatment for ER+ patients however, up to 50% of patients either do not respond or acquire resistance within 5 years of treatment. The MCF7-PKCa cell line was engineered to exogenously overexpress Protein Kinase C alpha (PKCa) which rendered it resistant to tamoxifen. MCF7-PKCa represents a valuable model for tamoxifen resistance and for screening the effectiveness of alternatives.
  • Research area: Cancer ; Drug Discovery & Development

  • For Research Use Only

Target Details

Application Details

Handling

  • Format: Frozen
  • Shipping conditions: Dry ice

Documentation

  • Available on request

References

  •   Xiong et al. 2017. J Med Chem. 60(4):1325-1342. PMID: 28117994.