CELL LINES
Contributor Information
- Name Debra Tonetti
- Institute University of Illinois Chicago
Tool Details
- Tool name: PKCa cell line
- Alternate names: MCF7
- Tool type: Cell Lines
- Tool sub-type: Continuous
- Parental cell line: MCF-7
- Organism: Human
- Tissue: Breast
- Cancer type: Breast; Tamoxifen Resistance
- Disease: Cancer
- Model: Cancer Model
- Description: Approximately 70% of breast cancer patients have estrogen receptor positive (ER+) tumors. The selective estrogen receptor modulator (SERM), tamoxifen, and aromatase inhibitors (AIs) represent first-line treatment for ER+ patients however, up to 50% of patients either do not respond or acquire resistance within 5 years of treatment. The MCF7-PKCa cell line was engineered to exogenously overexpress Protein Kinase C alpha (PKCa) which rendered it resistant to tamoxifen. MCF7-PKCa represents a valuable model for tamoxifen resistance and for screening the effectiveness of alternatives.
- Research area: Cancer; Drug Discovery & Development
- Additional notes: Engineered to over-express PKCa.
- For Research Use Only
Target Details
- Target: PKCÄÂĂÂ
Application Details
- Application notes: Engineered to over-express PKCÄÂĂÂ .
Handling
- Format: Frozen
- Shipping conditions: Dry ice
Documentation
- Available on request
Related Tools
References
- • Xiong et al. 2017. J Med Chem. 60(4):1325-1342. PMID: 28117994.
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