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Contributor Information

  • Name Fred Bunz
  • Institute Johns Hopkins University

Tool Details

  • Tool name: USP9x-deficient DLD-1 (with or without p53) cell line
  • Tool type: Cell Lines
  • Tool sub-type: Continuous
  • Parental cell line: DLD-1
  • Tissue: Colon
  • Disease: Cancer
  • Model: Knock-Out
  • Description: This cell line presents an opportunity to study the effect of loss of apoptotic control on colorectal cancer cells. Study of deubiquitinase Ups9X could act as a leap towards understanding apoptotic regulation and potentially lead to new drug targets for cancer.In this technology, the gene USP9X is knocked out of two colorectal DLD-1 cells. The gene knockout has been performed by rAAV-mediated homologous recombination. The technology also consists of a double knockout line without USP9X and p53, a tumor suppressor gene.
  • Research area: Cancer; Drug Discovery & Development

  • For Research Use Only

Target Details

  • Target: USP9X and p53

Application Details

Handling

  • Format: Frozen
  • Shipping conditions: Dry ice

Documentation

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  • Available on request

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References

  • •  Harris et al. 2012. Cancer Biol Ther. 13(13):1319-24. PMID: 22895071.