R-3327-AT6.1 cell line
- Name John Isaacs
- Institute Johns Hopkins University
Tool name: R-3327-AT6.1 cell line
Tool type: Cell Lines
Parental cell line:
Cancer type: Prostate cancer
Description: Somatic cell hybrids created from highly metastatic rat prostatic cancer cells and human chromosome 11 were created using micro cell-mediated chromosome transfer. The introduction of human chromosome 11 into the highly metastatic rat prostate cancer cells suppressed the metastatic ability of the cells without suppression of the in vivo growth rate or tumorigenicity of the hybrid cells.These cell hybrids can be used to pinpoint tumor suppressor genes on human chromosome 11. The cell line may also be used to screen for drugs that target the human tumor suppressor genes expressed. Such drugs can potentially be used as chemotherapeutic or chemopreventive agents for prostate cancer.
Research area: Cancer ; Drug Discovery & Development
- For Research Use Only
- • Ichikawa et al. 1992. Cancer Res. 52(12):3486-90. PMID: 1596907.