R-3327-3.1 cell line
- Name John Isaacs
- Institute Johns Hopkins University
Tool name: R-3327-3.1 cell line
Tool type: Cell Lines
Parental cell line:
Description: AT-3 originates from the spontaneous tumor (R3327) of the prostate identified by W.F. Dunning in a 22 month-old inbred Copenhagen male rat in 1961. R3327 has been maintained by continuous serial passage in rats for many years. Following subcutaneous transplantation in syngeneic male rats, AT-3 forms solid sheets of malignant cells with no indication of glandular function. AT-3.1 tumors grow continuously with a doubling time of 1.5-1.8 days regardless of the androgen status of the host and exhibit a high rate of metastasis to the lung and lymph nodes (>75% of rats inoculated sub-cutaneously develop distant metastases). The AT-3 subline can be used to study the effects of various types of cancer therapies on prostate cells. Together AT-3 and the related Dunning sublines also provide a valuable model for studying prostate malignancies both in vitro and in vivo.
Research area: Cancer ; Drug Discovery & Development
- For Research Use Only
- • Ichikawa et al. 1992. Cancer Res. 52(12):3486-90. PMID: 1596907.
- • Ichikawa et al. 1991. Cancer Res. 51(14):3788-92. PMID: 2065333.