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Contributor Information

  • Name John Isaacs
  • Institute Johns Hopkins University

Tool Details

  • Tool name: R-3327-MAT-Lu cell line
  • Tool type: Cell Lines
  • Parental cell line:
  • Cancer type: Prostate Cancer
  • Disease: Cancer
  • Description: This cell line was derived from the "H" subline and upon passage to the AT-1 subline (JHU-29) of the parental R3327 tumor. The "H" subline is a heterogeneous cell line as it is comprised of androgen-dependent and androgen-independent tumor cells. Passing this AT-1 sublinein intactmale rats allowed for the cloning of androgen-independent cell lines which gave rise to a fast-growing metastatic, anaplastic tumor (MAT) cell line which was further characterized to be highly metastatic to the lung (MAT-Lu). This cell line is a valuable model for the studying prostate malignancies both in vitro, and in vivo.DM 3852
  • Research area: Cancer ; Drug Discovery & Development

  • For Research Use Only

Target Details

Application Details

Handling

  • Format: Frozen
  • Growth medium:
  • Shipping conditions: Dry ice

Documentation

  • Available on request

References

  •   Isaacs et al. 1988. Prostate. 13(2):165-88. PMID: 3174494.
  •   Isaacs et al. 1986. Prostate. 9(3):261-81. PMID: 3774632.