R-3327-MAT-Lu cell line
- Name John Isaacs
- Institute Johns Hopkins University
Tool name: R-3327-MAT-Lu cell line
Tool type: Cell Lines
Parental cell line:
Cancer type: Prostate Cancer
Description: This cell line was derived from the "H" subline and upon passage to the AT-1 subline (JHU-29) of the parental R3327 tumor. The "H" subline is a heterogeneous cell line as it is comprised of androgen-dependent and androgen-independent tumor cells. Passing this AT-1 sublinein intactmale rats allowed for the cloning of androgen-independent cell lines which gave rise to a fast-growing metastatic, anaplastic tumor (MAT) cell line which was further characterized to be highly metastatic to the lung (MAT-Lu). This cell line is a valuable model for the studying prostate malignancies both in vitro, and in vivo.DM 3852
Research area: Cancer ; Drug Discovery & Development
- For Research Use Only
- • Isaacs et al. 1988. Prostate. 13(2):165-88. PMID: 3174494.
- • Isaacs et al. 1986. Prostate. 9(3):261-81. PMID: 3774632.