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Contributor Information

  • Name John Isaacs
  • Institute Johns Hopkins University

Tool Details

  • Tool name: R-3327 MAT-LyLu cell line
  • Tool type: Cell Lines
  • Cancer type: Genitourinary cancer
  • Disease: Cancer
  • Model: Cancer Model
  • Description: This cell line was derived from the "H" subline and was passaged to the AT-1 subline of the parental R3327 tumor. The "H" subline is a heterogeneous cell line as it is comprised of androgen-dependent and androgen-independent tumor cells. Passing this heterogeneous tumor cell population in intact male rats allowed for the cloning of androgen-independent cell lines which gave rise to a fast-growing metastatic, anaplastic tumor (MAT) cell line which was further characterized to be highly metastatic to the lungs and the lymph nodes (MAT-LyLu). This cell line is a valuable model for the studying prostate malignancies both in vitro and in vivo.
  • Research area: Cancer; Drug development
  • Cellosaurus ID: CVCL_3848

  • For Research Use Only

Target Details

  • Target: Metastatic anaplastic tumor (MAT) cell line, highly metastatic to the lungs and the lymph nodes (MAT-LyLu).

Application Details

Handling

  • Format: Frozen
  • Shipping conditions: Dry ice

Documentation

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References

  • •  Musialik et al. 2013. Oncol Rep. 29(5):1789-96. PMID: 23467722.
  • •  Isaacs et al. 1981. Invest Urol. 19(1):20-3. PMID: 7251319.