R-3327 AT.2 cell line
- Name John Isaacs
- Institute Johns Hopkins University
Tool name: R-3327 AT.2 cell line
Tool type: Cell Lines
Parental cell line:
Cancer type: Prostate Cancer
Description: AT-2 originates from the spontaneous tumor (R3327) of the prostate identified by W.F. Dunning in a 22 month-old inbred Copenhagen male rat in 1961. R3327 has been maintained by continuous serial passage in rats for many years. AT-2 was identified in 1981 and was the second of such anaplastic tumors to arise. Following subcutaneous transplantation in syngeneic male rats, AT-2 forms solid sheets of malignant cells with no indication of glandular function. These tumors are androgen-independent and grow continuously with a doubling time of approximately 2.5 days. AT-2 exhibits a low to moderate metastatic ability (<20% of rats inoculated sub-cutaneously develop distant metastases). The AT-2 subline can be used to study the effects of various types of cancer therapies on prostate cells.
Research area: Cancer ; Drug Discovery & Development
- For Research Use Only
- • Musialik et al. 2013. Oncol Rep. 29(5):1789-96. PMID: 23467722.
- • Isaacs et al. 1986. Prostate. 9(3):261-81. PMID: 3774632.