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Contributor Information

  • Name Saraswati Sukumar
  • Institute Johns Hopkins University

Tool Details

  • Tool name: Tamoxifen-resistant MCF7 Breast Cancer cell line
  • Tool type: Cell Lines
  • Tool sub-type: Continuous
  • Cancer type: Breast
  • Disease: Cancer
  • Model: Cancer Model
  • Description: MCF7 cells serve as a prototypic model system for human breast cancer and their response to secretive endocrine response modifiers (SERM) therapy. MCF7 cells, upon long term exposure to tamoxifen, acquire tam-resistance and continue to grow in the presence of tamoxifen. This provides a cell-based model , both in vitro and in vivo, for tam-resistant breast cancer, allows the testing of alternate therapies to tam-resistant breast cancer, or the high-throughput testing of drugs that might synergize with hormone based therapies.
  • Research area: Cancer; Drug Discovery & Development
  • Cellosaurus ID: CVCL_EG55

  • For Research Use Only

Target Details

  • Target: tamoxifen resistant breast cancer

Application Details

Handling

  • Format: Frozen
  • Shipping conditions: Dry ice

Documentation

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  • Available on request

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References

  • •  Wu et al. 2015. Mol Cell Proteomics. 14(11):2887-900. PMID: 26330541.