Tamoxifen-resistant MCF7 Breast Cancer cell line
- Name Saraswati Sukumar
- Institute Johns Hopkins University
Tool name: Tamoxifen-resistant MCF7 Breast Cancer cell line
Tool type: Cell Lines
Tool sub-type: Continuous
Parental cell line:
Cancer type: Breast Cancer
Description: MCF7 cells serve as a prototypic model system for human breast cancer and their response to secretive endocrine response modifiers (SERM) therapy. MCF7 cells, upon long term exposure to tamoxifen, acquire tam-resistance and continue to grow in the presence of tamoxifen. This provides a cell-based model , both in vitro and in vivo, for tam-resistant breast cancer, allows the testing of alternate therapies to tam-resistant breast cancer, or the high-throughput testing of drugs that might synergize with hormone based therapies.
Research area: Cancer ; Drug Discovery & Development
- For Research Use Only
- • Wu et al. 2015. Mol Cell Proteomics. 14(11):2887-900. PMID: 26330541.