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Contributor Information

  • Name Lawrence Pfeffer
  • Institute The University of Tennessee Health Science Center

Tool Details

  • Tool name: STAT2-Defective Mutant Daudi (RST2) cell line
  • Tool type: Cell Lines
  • Tool sub-type: Continuous
  • Parental cell line: Human Daudi Burkitt Lymphoma cell line
  • Organism: Human
  • Tissue: Blood
  • Cancer type: Burkitt lymphoma
  • Disease: Cancer
  • Model: Transgenic
  • Description: This cell line can be used to study drug resistance developed after treatment with interferon. Interferon therapy has been proved as a successful treatment for various types of cancer, however it develops resistance in patients. This cell line was not affected by the antiviral, antiproliferative, and gene-inducing actions of IFN.
  • Research area: Cancer
  • Production details: Isolated from IFN-sensitive Daudi cell line by growth in the continuous presence of IFN

  • For Research Use Only

Target Details

Application Details

Handling

  • Format: Frozen
  • Growth medium: RPMI1640 and 10% defined calf serum; Subculture 1:4 twice a week, maintain 1 and 10X10^5 cells/mL
  • Shipping conditions: Dry ice

Documentation

  • Available on request

References

  •   Schmeisser et al. 2013. Autophagy. 9(5):683-96. PMID: 23419269.
  •   Du et al. 2009. J Biol Chem. 284(41):27808-15. PMID: 19687011.