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Contributor Information

  • Name Thorbald Van Hall
  • Institute Leiden University and Leiden University Medical Center; Stichting Oncode Institute

Tool Details

  • Tool name: RMA-S.Trh4 cells
  • Tool type: Cell Lines
  • Tool sub-type: Continuous
  • Parental cell line: RMA-S
  • Organism: Mouse
  • Tissue: Lymphatic Tissue
  • Cancer type: Mouse Leukemia
  • Disease: Cancer
  • Description: This cell line provides a model to help to understand T-cell recognition through Trh4 expression. ER-resident ceramide synthase Trh4 is a prototypic example of a neo-antigen selectively presented by cells through various pathways. RMA-S lymphoma cells are TAP-deficient on account of an incomplete TAP2 chain, whereas RMA cells have their TAP chain intact.The Trh4 peptide is only presented on cells with impaired TAP function through the classical MHC I pathway. This cell line presents said Trh4 and helps to characterise this pathway.
  • Research area: Cancer

  • For Research Use Only

Target Details

Application Details

Handling

  • Format: Frozen
  • Growth medium:
  • Storage conditions: Liquid Nitrogen
  • Shipping conditions: Dry ice
  • Mycoplasma free: Yes
  • Biosafety level: 1

Documentation

  • Available on request

References

  •   Oliveira et al. 2011. Eur J Immunol. 41(11):3114-24. PMID: 21898382.