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Contributor Information

  • Name Thorbald Van Hall
  • Institute Leiden University and Leiden University Medical Center; Stichting Oncode Institute

Tool Details

  • Tool name: RMA-S.Trh4 cells
  • Tool type: Cell Lines
  • Tool sub-type: Continuous
  • Parental cell line: RMA-S
  • Organism: Mouse
  • Tissue: Lymphatic Tissue
  • Cancer type: Blood cancer
  • Disease: Cancer
  • Model: Tumour line
  • Description: This cell line provides a model to help to understand T-cell recognition through Trh4 expression. ER-resident ceramide synthase Trh4 is a prototypic example of a neo-antigen selectively presented by cells through various pathways. RMA-S lymphoma cells are TAP-deficient on account of an incomplete TAP2 chain, whereas RMA cells have their TAP chain intact.The Trh4 peptide is only presented on cells with impaired TAP function through the classical MHC I pathway. This cell line presents said Trh4 and helps to characterise this pathway.
  • Research area: Cancer
  • Production details: Retroviral transduction of the mouse Trh4 gene in an IRES-GFP construct
  • Cellosaurus ID: CVCL_2180

  • For Research Use Only

Target Details

  • Target: Trh4

Application Details


  • Format: Frozen
  • Storage conditions: Liquid Nitrogen
  • Shipping conditions: Dry ice
  • Mycoplasma free: Yes
  • Biosafety level: 1



  •   Oliveira et al. 2011. Eur J Immunol. 41(11):3114-24. PMID: 21898382.