CELL LINES
Contributor Information
- Name Rita Perlingeiro Kyba
- Institute The University of Minnesota Twin Cities
Tool Details
- Tool name: DM1-2 hiPS cell line
- Alternate names: Myotonic dystrophy 1 (DM-1)
- Tool type: Cell Lines
- Parental cell line: skin fibroblasts from a diagnosed DM1 patient
- Organism: Human
- Disease: Muscular dystrophy
- Model: Stem Cells
- Description: Myotonic dystrophy is a genetic disease characterized by a loss of muscle function. Myotonic dystrophy type 1 (DM1), the most common form of myotonia, is caused by mutations in the DMPK gene. Currently, there is no cure or treatment for DM1. 4 total cell lines are available: 2 undifferentiated hiPSC lines from two DM1 patients (DM1-1 hiPS cell line, DM1-2 hiPS cell line) and 2 differentiated skeletal muscle cell lines (DM1-1 iPAX7-hiPS cell line and DM1-2 iPAX7-hiPS cell line).
- Research area: Cell Signaling & Signal Transduction; Drug Discovery & Development
- Production details: To generate a cell-based model for DM1, researchers obtained a sample of skin fibroblasts from two diagnosed DM1 patients. These fibroblasts (DM1-1 and DM1-2) were reprogrammed to hiPS cells via the Sendai virus method.
- For Research Use Only
Target Details
- Target: myotonic dystrophy protein kinase (DMPK)
Application Details
Handling
- Format: Frozen
- Shipping conditions: Dry ice
Documentation
- Available on request
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