CELL LINES

Contributor Information
- Name Julian Downward
- Institute The Francis Crick Institute
Tool Details
- Tool name: CT26 TTPKO cell line
- Alternate names: TTP
- Tool type: Cell Lines
- Tool sub-type: Continuous
- Parental cell line: CT26 ATCC-CRL-2638
- Organism: Mouse
- Disease: Cancer
- Description: CRISPR/Cas tristetraprolin (TTP) Knock-out KRAS mutant colon carcinoma cell line. In some immunoresistant tumours, PD-L1 expression is upregulated by RAS activation. Via the MEK pathway, the MK2 kinase phosporylates and inhibits TTP, which negatively regulates PD-L1 expression. PD-L1 is a therapeutic target to check the immune evasion mechanism of some cancers.
- Research area: Cancer ; Cell Cycle ; Cell Signaling & Signal Transduction
- For Research Use Only
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References
- • Coelho et al. 2017. Immunity. 47(6):1083-1099.e6. PMID: 29246442.