MCF7 ZsGreen-ZNF703 Overexpressing Cell Line
- Name Carlos Caldas
- Institute University of Cambridge
Tool name: MCF7 ZsGreen-ZNF703 Overexpressing Cell Line
Tool type: Cell Lines
Tool sub-type: Continuous
Parental cell line: MCF7
Description: This is a derivative of the MCF7 breast cancer cell line engineered to overexpress Zinc Finger Protein 703 (ZNF703). ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium. Manipulation of ZNF703 expression in the luminal MCF7 cell line modified the effects of TGF? on proliferation. ZNF703 drives the exprsesion of the green fluorescent protein ZsGreen.
Please note there is a MCF7 Lenti-control cell line available to use as a negative control with this cell line (see Related tab).
Research area: Cancer ; Cell Signaling & Signal Transduction
- For Research Use Only
- • Holland et al. 2011. EMBO Mol Med. 3(3):167-80. PMID: 21337521.