UM-UC-1 (Human bladder transitional cell carcinoma) cell line
- Name H. Grossman ; Anita Sabichi
- Institute University of Michigan
Tool name: UM-UC-1 (Human bladder transitional cell carcinoma) cell line
Alternate names: UM-UC-1
Tool type: Cell Lines
Tissue: Lymphatic Tissue
Cancer type: Genitourinary cancer
Growth properties: Adherent
Model: Cancer Model
Description: UM-UC-1 are a human transitional cell carcinoma originating from lymphatic metastasis of transitional cell carcinoma of the bladder of a 26-year old black male.
These cells were assessed for their susceptibility to adenoviral mediated gene delivery, tumor growth in nude mice and differences in genetic alterations. These assays allowed for characterization of some of the most important features in each of the respective lines in an effort to more accurately establish common observed phenomena across cells of the same type of neoplasm.
Tumorigenicity studies in nude mice revealed the UM-UC-1 produced tumors, 1-1.5 cm in diameter in < 3 weeks. UM-UC-1 was more resistant to adenoviral gene transduction than several of the other cells evaluated. UM-UC-1 did, however, have one of the highest levels of Coxsackie adenovirus receptor (CAR) expression of the cells tested.
Research area: Cancer
- For Research Use Only
- • Sabichi et al. 2006. J Urol. 175(3 Pt 1):1133-7. PMID: 16469639.
- • Grossman et al. 1984. J Urol. 132(4):834-7. PMID: 6471236.