CELL LINES
Contributor Information
- Name H. Grossman ; Anita Sabichi
- Institute University of Michigan
Tool Details
- Tool name: UM-UC-1 (Human bladder transitional cell carcinoma) cell line
- Alternate names: UM-UC-1
- Tool type: Cell Lines
- Organism: Human
- Tissue: Lymphatic Tissue
- Cancer type: Genitourinary cancer
- Disease: Cancer
- Growth properties: Adherent
- Model: Cancer Model
- Description: UM-UC-1 are a human transitional cell carcinoma originating from lymphatic metastasis of transitional cell carcinoma of the bladder of a 26-year old black male. These cells were assessed for their susceptibility to adenoviral mediated gene delivery, tumor growth in nude mice and differences in genetic alterations. These assays allowed for characterization of some of the most important features in each of the respective lines in an effort to more accurately establish common observed phenomena across cells of the same type of neoplasm. Tumorigenicity studies in nude mice revealed the UM-UC-1 produced tumors, 1-1.5 cm in diameter in < 3 weeks. UM-UC-1 was more resistant to adenoviral gene transduction than several of the other cells evaluated. UM-UC-1 did, however, have one of the highest levels of Coxsackie adenovirus receptor (CAR) expression of the cells tested.
- Research area: Cancer
- For Research Use Only
Target Details
Application Details
Handling
- Format: Frozen
- Growth medium: Cells were grown in Dulbecco's modified Eagle's medium (DMEM) containing 10% heat inactivated Fetal Bovine Serum (FBS) and were supplemented with 1% penicillin and streptomycin at 37?°C in 5% CO2 environment.
- Shipping conditions: Dry ice
Documentation
Related Tools
References
- • Sabichi et al. 2006. J Urol. 175(3 Pt 1):1133-7. PMID: 16469639.
- • Grossman et al. 1984. J Urol. 132(4):834-7. PMID: 6471236.
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