UM-UC-13 (Human transitional cell carcinoma lymphatic metastasis) cell line
- Name H. Grossman ; Anita Sabichi
- Institute University of Michigan
Tool name: UM-UC-13 (Human transitional cell carcinoma lymphatic metastasis) cell line
Alternate names: UM-UC-13
Tool type: Cell Lines
Tissue: Lymphatic Tissue
Cancer type: Human bladder transitional cell carcinoma
Growth properties: Adherent
Model: Cancer Model
Description: UM-UC-13 are a human transitional cell carcinoma originating from lymphatic metastases of transitional cell carcinomas of the bladder of a 26-year old black male.
These cells were assessed for their susceptibility to adenoviral mediated gene delivery, tumor growth in nude mice and differences in genetic alterations. Tumorigenicity studies in nude mice revealed the UM-UC-13 produced tumors, 1-1.5 cm in diameter in 1 month. UM-UC-13 demonstrated efficient gene transduction via an adenoviral vector when compared to several of the other cells evaluated. UM-UC-13 also demonstrated no sign of Coxsackie adenovirus receptor (CAR) expression.
These assays allowed for characterization of some of the most important features in each of the respective lines in an effort to more accurately establish commonly observed phenomena across cells of the same type of neoplasm.
Research area: Cancer
- For Research Use Only
- • Sabichi et al. 2006. J Urol. 175(3 Pt 1):1133-7. PMID: 16469639.
- • Grossman et al. 1984. J Urol. 132(4):834-7. PMID: 6471236.