CELL LINES
Contributor Information
- Name Carmel McConville
- Institute University of Birmingham
Tool Details
- Tool name: BCH-N-MS Neuroblastoma cell line
- Tool type: Cell Lines
- Tool sub-type: Primary
- Organism: Human
- Tissue: Abdomen
- Gender: Male
- Cancer type: Neurological cancer
- Disease: Cancer
- Growth properties: Cell lines may contain both neuronal and stromal/substrate adherent (N & S) cell types - this is a recognized characteristic of many neuroblastoma cell lines
- Model: MYCN gene amplification present in sample
- Application: Neuroblastoma cells have been used for the following: - Investigation of metabolic profiles generated by in vitro H MRS - Characterisation of genetic pathways - Discovery of epigenetically deregulated genes during neuroblastoma tumorigenesis, using genome wide DNA methylation analysis - Functional investigation of MEGF10 knockdown
- Description: Neuroblastoma is the most common extracranial solid malignancy in children. The disease possesses a broad range of clinical phenotypes with widely varying prognoses. Standard clinical and pathological assessments do not always differentiate reliably between tumor subtypes and, therefore, genetic markers are now playing an increasingly important role in treatment decisions.
- Research area: Cancer
- Cellosaurus ID: TBC
- Additional notes: Karyotype data available on request STR data available on request
- For Research Use Only
Target Details
Application Details
- Application: Neuroblastoma cells have been used for the following: - Investigation of metabolic profiles generated by in vitro H MRS - Characterisation of genetic pathways - Discovery of epigenetically deregulated genes during neuroblastoma tumorigenesis, using genome wide DNA methylation analysis - Functional investigation of MEGF10 knockdown
- Application notes: Tissue Site: Abdomen Patient Sex: Male MYCN gene amplification present in sample Neuroblastoma cells have been used for the following: - Investigation of metabolic profiles generated by in vitro H MRS - Characterisation of genetic pathways - Discovery of epigenetically deregulated genes during neuroblastoma tumorigenesis, using genome wide DNA methylation analysis - Functional investigation of MEGF10 knockdown Karyotype data available on request STR data available on request
Handling
- Format: Frozen
- Growth medium: Growth medium: DME/F12+15% fetal calf serum + glutamine + non-essential amino acids.
- Shipping conditions: Dry ice
Documentation
References
- • Peet et al. 2007. NMR Biomed. 20(7):692-700. PMID: 17506115.
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