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Contributor Information

  • Name Carmel McConville
  • Institute University of Birmingham

Tool Details

  • Tool name: BCH-P-SS pNET cell line
  • Alternate names: Askin Tumour
  • Tool type: Cell Lines
  • Tool sub-type: Primary
  • Parental cell line:
  • Organism: Human
  • Tissue: Chest Wall
  • Gender: Female
  • Cancer type: Neuroblastoma pNET (peripheral primitive neuroectodermal tumour)
  • Disease: Cancer
  • Application: Neuroblastoma cells have been used for the following: - Investigation of metabolic profiles generated by in vitro H MRS - Characterisation of genetic pathways - Discovery of epigenetically deregulated genes during neuroblastoma tumorigenesis, using genome wide DNA methylation analysis - Functional investigation of MEGF10 knockdown
  • Description: Among small blue round cell tumors, primitive neuroectodermal tumors (PNETs) are a group of Ewing sarcoma family of tumors that are highly aggressive, poorly differentiated and form a group of tumors defined by their appearance that are thought to derive from postganglionic parasympathetic primordial cells located throughout the parasympathetic autonomic nervous system. Iran J Pediatr. 2014 Apr; 24(2): 221222. PMID: 25535544 Neuroblastoma is the most common extracranial solid malignancy in children. The disease possesses a broad range of clinical phenotypes with widely varying prognoses. Standard clinical and pathological assessments do not always differentiate reliably between tumor subtypes and, therefore, genetic markers are now playing an increasingly important role in treatment decisions.
  • Research area: Cancer

  • For Research Use Only

Target Details

Application Details

  • Application: Neuroblastoma cells have been used for the following: - Investigation of metabolic profiles generated by in vitro H MRS - Characterisation of genetic pathways - Discovery of epigenetically deregulated genes during neuroblastoma tumorigenesis, using genome wide DNA methylation analysis - Functional investigation of MEGF10 knockdown

Handling

  • Format: Frozen
  • Growth medium: Growth medium: DME/F12+15% fetal calf serum + glutamine + non-essential amino acids.
  • Shipping conditions: Dry ice

Documentation

  • Available on request