BCH-P-SS pNET cell line
- Name Carmel McConville
- Institute University of Birmingham
Tool name: BCH-P-SS pNET cell line
Alternate names: Askin Tumour
Tool type: Cell Lines
Tool sub-type: Primary
Parental cell line:
Tissue: Chest Wall
Cancer type: Neuroblastoma pNET (peripheral primitive neuroectodermal tumour)
Application: Neuroblastoma cells have been used for the following:
- Investigation of metabolic profiles generated by in vitro H MRS
- Characterisation of genetic pathways
- Discovery of epigenetically deregulated genes during neuroblastoma tumorigenesis, using genome wide DNA methylation analysis
- Functional investigation of MEGF10 knockdown
Description: Among small blue round cell tumors, primitive neuroectodermal tumors (PNETs) are a group of Ewing sarcoma family of tumors that are highly aggressive, poorly differentiated and form a group of tumors defined by their appearance that are thought to derive from postganglionic parasympathetic primordial cells located throughout the parasympathetic autonomic nervous system.
Iran J Pediatr. 2014 Apr; 24(2): 221222.
Neuroblastoma is the most common extracranial solid malignancy in children. The disease possesses a broad range of clinical phenotypes with widely varying prognoses.
Standard clinical and pathological assessments do not always differentiate reliably between tumor subtypes and, therefore, genetic markers are now playing an increasingly important role in treatment decisions.
Research area: Cancer
- For Research Use Only