CELL LINES
Contributor Information
- Name Carmel McConville
- Institute University of Birmingham
Tool Details
- Tool name: BCH-P-SS pNET cell line
- Alternate names: Askin Tumour
- Tool type: Cell Lines
- Tool sub-type: Primary
- Organism: Human
- Tissue: Chest Wall
- Gender: Female
- Cancer type: Neurological cancer
- Disease: Cancer
- Growth properties: Cell lines may contain both neuronal and stromal/substrate adherent (N & S) cell types - this is a recognized characteristic of many neuroblastoma cell lines
- Model: Cancer Model
- Application: Neuroblastoma cells have been used for the following: - Investigation of metabolic profiles generated by in vitro H MRS - Characterisation of genetic pathways - Discovery of epigenetically deregulated genes during neuroblastoma tumorigenesis, using genome wide DNA methylation analysis - Functional investigation of MEGF10 knockdown
- Description: Among small blue round cell tumors, primitive neuroectodermal tumors (PNETs) are a group of Ewing sarcoma family of tumors that are highly aggressive, poorly differentiated and form a group of tumors defined by their appearance that are thought to derive from postganglionic parasympathetic primordial cells located throughout the parasympathetic autonomic nervous system. Iran J Pediatr. 2014 Apr; 24(2): 221222. PMID: 25535544 Neuroblastoma is the most common extracranial solid malignancy in children. The disease possesses a broad range of clinical phenotypes with widely varying prognoses. Standard clinical and pathological assessments do not always differentiate reliably between tumor subtypes and, therefore, genetic markers are now playing an increasingly important role in treatment decisions.
- Research area: Cancer
- Cellosaurus ID: TBC
- Additional notes: Karyotype data available on request STR data available on request
- For Research Use Only
Target Details
Application Details
- Application: Neuroblastoma cells have been used for the following: - Investigation of metabolic profiles generated by in vitro H MRS - Characterisation of genetic pathways - Discovery of epigenetically deregulated genes during neuroblastoma tumorigenesis, using genome wide DNA methylation analysis - Functional investigation of MEGF10 knockdown
- Application notes: Tissue Site: Chest Wall Patient Sex: Female Neuroblastoma cells have been used for the following: - Investigation of metabolic profiles generated by in vitro H MRS - Characterisation of genetic pathways - Discovery of epigenetically deregulated genes during neuroblastoma tumorigenesis, using genome wide DNA methylation analysis - Functional investigation of MEGF10 knockdown Karyotype data available on request STR data available on request
Handling
- Format: Frozen
- Growth medium: Growth medium: DME/F12+15% fetal calf serum + glutamine + non-essential amino acids.
- Shipping conditions: Dry ice
Documentation
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