CELL LINES

Contributor Information
- Name Bernhard Singer
- Institute LeukoCom
Tool Details
- Tool name: HEK293-CEACAM3-Fc cell line
- Alternate names: Carcinoembryonic antigen-related cell adhesion molecule 3, CD66d, Cluster of Differentiation 66d, CGM1
- Tool type: Cell Lines
- Tool sub-type: Continuous
- Parental cell line: HEK293
- Organism: Human
- Tissue: Kidney
- Growth properties: Adherent
- Model: Transgenic
- Conditional: No
- Description: CEACAM-3 is a 31 - 34 kDa member of the CEACAM subfamily of the CEA family of proteins. It is expressed by neutrophils and serves as a microbial receptor for a wide range of microorganisms. Mature human CEACAM-3 is a 218 amino acid (aa) type I transmembrane glycoprotein. Its extracellular domain (aa 35 - 155) shows one V-type Ig-like domain (aa 35 - 142). There are two alternate splice forms of CEACAM-3. One shows a 40 aa substitution for the C-terminal 116 amino acids (aa 137 - 252), while a second shows a 31 aa substitution for the C-terminal 71 amino acids. No definitive rodent CEACAM-3 has been reported
- Research area: Cancer; Cell biology; Immunology
- Production details: Overexpression of human CEACAM3-Fc Chimera Protein
- For Research Use Only