CELL LINES
Contributor Information
- Name Bernhard Singer
- Institute LeukoCom
Tool Details
- Tool name: HEK293-CEACAM5-Fc cell line
- Alternate names: Carcinoembryonic antigen-related cell adhesion molecule 5, CD66e, Cluster of Differentiation 66e
- Tool type: Cell Lines
- Tool sub-type: Continuous
- Parental cell line: HEK293
- Organism: Human
- Tissue: Kidney
- Growth properties: Adherent
- Model: Transgenic
- Conditional: No
- Description: CEACAM-5 is expressed primarily by epithelial cells and functions as a calcium-independent adhesion molecule through homophilic and heterophilic interactions with CEACAM-1. CEACAM-5 is restricted to the apical face of intestinal epithelial cells in the adult but is more diffuse during embryonic development and in tumours. CEACAM-5 is upregulated in a wide variety of human tumours and is a commonly used cancer marker. It promotes tumour cell migration, invasion, adhesion, and metastasis. It also contributes to tumour formation by maintaining cellular proliferation in the presence of differentiation stimuli, and by blocking apoptosis following loss of ECM anchorage (anoikis). Cell surface expression of CEACAM-5 on tumour cells prevents the adhesion of CEACAM-1 expressing NK cells and provides protection from NK-mediated lysis
- Research area: Cancer; Adhesion; Immunology
- Production details: Overexpression of human CEACAM5-Fc Chimera Protein
- For Research Use Only
Target Details
- Target: CEACAM5
Application Details
Handling
- Format: Frozen
- Growth medium: DMEM + 10% FBS
- Shipping conditions: Dry ice
Documentation
- Available on request
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