HEK293-MacCEACAM1-Fc cell line

It engages in homotypic adhesion and heterotypic adhesion with CEACAM-3/CD66d and CEACAM-6/CD66c. On neutrophils, CEACAM-1 additionally binds to dendritic cell DC-SIGN via its Lewis-x moiety, inducing dendritic cell maturation and a subsequent Th1-type response

Contributors

Institute
LeukoCom
Cat. #: 160699
Tool sub type: Continuous
Unit size: 1×10^6 cells / vial
Research Fields: Cancer;Cell biology
Organism: Human
Tissue: Kidney
Model: Transgenic
Growth properties: Adherent
Alternate name: Carcinoembryonic antigen-related cell adhesion molecule 1, CD66a, Cluster of Differentiation 66a
Product description: CEACAM-1, also known as CD66a, is an immunoglobulin superfamily protein that is expressed on neutrophils, activated NK cells, bile duct and colonic epithelial cells, and endothelial cells. CEACAM-1 is heavily glycosylated and carries high mannose residues and (sialyl) Lewis-x. It is expressed as at least three soluble and seven transmembrane isoforms, with variations occurring in both the ECD and cytoplasmic region. It engages in homotypic adhesion and heterotypic adhesion with CEACAM-3/CD66d…
Conditional: No
Production details: Overexpression of macaque CEACAM1-Fc Chimera Protein
Parental cell line: HEK293
Format: Frozen
Storage conditions: Liquid Nitrogen
Shipping conditions: Dry ice
Growth medium: DMEM + 10% FBS
Recommended controls: HEK293 parental line
Mycoplasma free: Yes
Biosafety level: 1

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