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Contributor Information

  • Institute LeukoCom

Tool Details

  • Tool name: HEK293-MacCEACAM1-Fc cell line
  • Alternate names: Carcinoembryonic antigen-related cell adhesion molecule 1, CD66a, Cluster of Differentiation 66a
  • Tool type: Cell Lines
  • Tool sub-type: Continuous
  • Parental cell line: HEK293
  • Organism: Human
  • Tissue: Kidney
  • Description: CEACAM-1, also known as CD66a, is an immunoglobulin superfamily protein that is expressed on neutrophils, activated NK cells, bile duct and colonic epithelial cells, and endothelial cells. CEACAM-1 is heavily glycosylated and carries high mannose residues and (sialyl) Lewis-x. It is expressed as at least three soluble and seven transmembrane isoforms, with variations occurring in both the ECD and cytoplasmic region. It engages in homotypic adhesion and heterotypic adhesion with CEACAM-3/CD66d and CEACAM-6/CD66c. On neutrophils, CEACAM-1 additionally binds to dendritic cell DC-SIGN via its Lewis-x moiety, inducing dendritic cell maturation and a subsequent Th1-type response
  • Research area: Cancer ; Adhesion

  • For Research Use Only

Target Details

Application Details

Handling

  • Format: Frozen
  • Growth medium: DMEM + 10% FBS
  • Storage conditions: Liquid Nitrogen
  • Shipping conditions: Dry ice
  • Mycoplasma free: Yes
  • Biosafety level: 1

Documentation

  • Available on request