OV4Carbo Cell Line

Platinum-resistant HGSC cancer cells.

Contributors

Inventor Institute
Michelle Lockley Queen Mary University of London, UK
Cat. #: 161761
Cancer types: Gynaecologic cancer
Research Fields: Cancer
Organism: Human
Tissue: Ovary
Gender: Female
Model: Mutant
Growth properties: Adherent
Primary citation: J I Hoare et al. 2022. Gynecol Oncol. 167(1):96-106. PMID: 35918200.
Product description: Platinum-resistant HGSC cancer cells with a growth advantage in the presence of therapy that expand to create drug-resistant tumours.
Gender: Female
CRISPR: No
Production details: Cells were cultured in vitro in increasing concentrations of either cisplatin or carboplatin until an increase in IC50 between two and ten-fold was achieved to reflect the resistance observed in human patients
Parental cell line: OVCAR4 cell lines
Model description: Platinum-resistant HGSC in vivo cell line
Growth medium: DMEM containing 10% FBS and 1% penicillin/streptomycin. Cells should be cultured without drug but used at low passage to ensure drug resistance is maintained.
Temperature: 37° C
Mycoplasma free: Yes
References:

H Hockings et al. 2022. Cancer Res. 85(18):3503-3517.PMID: 40299825

J I Hoare et al. 2022. Gynecol Oncol. 167(1):96-106. PMID: 35918200.

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