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Contributor Information

  • Name Christoper Stipp
  • Institute University Of Iowa Research Foundation
  • Primary citation Feddersen et al.2019. Cancer Res. 79(19). PMID: 31416849

Tool Details

  • Tool name: C6.1 cell line
  • Alternate names: C6.1
  • Tool type: Cell Lines
  • Parental cell line: A375 Melanoma (ATCC)
  • Organism: Human
  • Donor: A375 (ATCC) -human melanoma cell line of a solid tumor from a 54-year-old female.
  • Tissue: Skin
  • Gender: Female
  • Cancer type: Skin cancer
  • Morphology: Compact Morphology
  • Description: Spontaneous vemurafenib resistant A375 Melanoma Clones. Shows frequent alterations of BRAF^V600 protein. No increased VAV1 protein levels.
  • Research area: Cancer; Drug development
  • Production details: Long-term cultures of A375 cells in 3 ?M vemurafenib. Spontaneous vemurafenib-resistant clones and populations were created after 2–3 and 4–6 weeks cultured in 3 mm vemurafenib. Maintained in media with 3 mm vemurafenib.

  • For Research Use Only

Target Details

Application Details

Handling

  • Growth medium: DMEM(Gibco) suplemented with penicillin/streptomycin (Gibco) and 10% FBS (Gibco).

Documentation

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References

  • •  Feddersen et al.2019. Cancer Res. 79(19).PMID: 31416844
  • •  Zhu et al. 2022. npj Precis. Onc. PMID: 36271147