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Contributor Information

  • Name Joyce Taylor-Papadimitriou ; Joy Burchell
  • Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details

  • Tool name: MUC1 Mouse
  • Alternate names: ADMCKD, ADMCKD1, Breast carcinoma associated antigen DF3, Breast carcinoma-associated antigen DF3, CA 15-3, CA15 3, CA15 3 antigen, CA15.3, Cancer antigen 15-3, Carcinoma associated mucin, Carcinoma-associated mucin, CD 227, CD227
  • Tool type: Experimental models
  • Tool sub-type: Mouse
  • Cancer type: Adenocarcinoma
  • Disease: Cancer; Adenocarcinoma; Drug metabolism & toxicity
  • Conditional description: Genomic fragment containing complete MUC1 gene and promoter region, enabling tissue-specific MUC1 expression pattern.
  • Genetic background and cross history: A linear genomic fragment, containing the MUC1 gene and promoter, was injected into fertilized embryos (various backgrounds), and implanted into pseudopregnant mice. Transgenic mice were identified by Southern blot, and maintained as homozygotes.
  • Phenotype: Mice demonstrate tissue-specific PEM expression pattern and glycosylation analogous to that observed in human tissues.
  • Zygosity: Homozygous
  • Description: Model for preclinical study of anti-MUC1 vaccines/immunotherapies;
  • Research area: Cancer; Cell biology; Cell signaling and signal transduction; Genetics
  • Production details: A linear genomic fragment, containing the MUC1 gene and promoter, was injected into fertilized embryos (various backgrounds), and implanted into pseudopregnant mice. Transgenic mice were identified by Southern blot, and maintained as homozygotes.
  • Additional notes: Mice demonstrate tissue-specific PEM expression pattern and glycosylation analogous to that observed in human tissues.

  • For Research Use Only

Target Details

  • Target: Human MUC1 (mucin-like protein 1) / PEM (polymorphic epithelial mucin)

Application Details

Handling

  • Shipping conditions: Embryo/Spermatoza- Dry Ice

Documentation

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References

  • •  Peat et al. 1992. Cancer Res. 52(7):1954-60. PMID: 1372533.
  • •  Tissue-specific expression of a human polymorphic epithelial mucin (MUC1) in transgenic mice.