EXPERIMENTAL MODELS
Contributor Information
- Name Fiona Watt
- Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Tool Details
- Tool name: K14dNb Mouse
- Tool type: Experimental models
- Tool sub-type: Mouse
- Cancer type: Colorectal; melanoma
- Disease: Cancer; Telogen effluvium;
- Model: Knock-Out
- Conditional: Yes
- Conditional description: Conditional expression of deltaNbeta-cateninER under Keratin 14 promoter giving tissue-specific epidermal expression.
- Genetic background and cross history: A deltaNbeta-cateninER transgenic vector, containing an N-terminally truncated beta-catenin cDNA fused to the hormone-binding domain of a mutant mouse estragen receptor under the control of the keratin 14 promoter, was injected into fertilised CBA/C57BL6 ooctyes. Founders were backcrossed to establish transgenic lines.
- Phenotype: Skin abnormalities (hair follicle);
- Zygosity:
- Description: In vivo study of beta-catenin activation in skin; model for hair growth & follicle formation;
- Research area: Cancer; Cell Signaling & Signal Transduction; Genetic studies; Neurobiology; Stem Cell Biology
- Production details: A deltaNbeta-cateninER transgenic vector, containing an N-terminally truncated beta-catenin cDNA fused to the hormone-binding domain of a mutant mouse estragen receptor under the control of the keratin 14 promoter, was injected into fertilised CBA/C57BL6 ooctyes. Founders were backcrossed to establish transgenic lines.
- Additional notes:
- For Research Use Only
Target Details
- Target: Beta-catenin N-terminal truncation (deltaNbeta-catenin) fused with estrogen receptor (ER)
Application Details
Handling
- Shipping conditions: Embryo/Spermatoza- Dry Ice
Documentation
- Available on request
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